Acid Dreams | The CIA, LSD and the Sixties Rebellion

In the spring of 1942, General William "Wild Bill" Donovan, chief of the OSS, the CIA's wartime predecessor, assembled a half-dozen prestigious American scientists and asked them to undertake a top-secret research program. Their mission, Donovan explained, was to develop a speech-inducing drug for use in intelligence interrogations. He insisted that the need for such a weapon was so acute as to warrant any and every attempt to find it.

The use of drugs by secret agents had long been a part of cloak-and-dagger folklore, but this would be the first concerted attempt on the part of an American espionage organization to modify human behavior through chemical means. "We were not afraid to try things that had never been done before," asserted Donovan, who was known for his freewheeling and unconventional approach to the spy trade. The OSS chief pressed his associates to come up with a substance that could break down the psychological defenses of enemy spies and POWs, thereby causing an uninhibited disclosure of

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