Death from GHB
Death from GHB
March 5, 2011
Case series of 226 γ-hydroxybutyrate-associated deaths: lethal toxicity and trauma. Zvosek DL et al. Am J Emer Med 2011;29:319-332
Abstract
This long paper retrospectively reviews an extensive series of γ-hydroxybutyrate (GHB) fatalities culled from various sources, including medical examiner/coroner records, state health departments and toxicology labs, law enforcement agencies, and cases reported to the website www.ProjectGHB.org. Cases were included if levels of GHB or 1,4-Butanediol (BD) in various biologic specimens exceeded pre-set cutoffs.
A total of 226 BHG-associated deaths were identified: 213 directly caused by drug toxicity, 13 from trauma judged to be associated with the drug (6 motor vehicle crashes, 6 drownings, 1 fire). Deaths from drug toxicity were most likely caused by respiratory depression.
The authors make a number of important points:
Although GHB is often mistakenly considered safe if taken alone, a number of deaths in this report...